Overall, Spruce Pine works fairly well with most tools, though the resin can gum up tools and clog sandpaper. Spruce Pine glues and finishes well.
Working with pine has been reported to cause allergic skin reactions and/or asthma-like symptoms in some people. See the articles Wood Allergies and Toxicity and Wood Dust Safety for more information.
Spruce Pine has a lower density than most other species in the Southern Yellow Pine grouping, hence its distribution is more generally restricted to local lumber needs and plywood production. The wood is sometimes sold as Southern Yellow Pine for a moderate price.